BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuGlucagonomaMEN I - glucagonomaGlucagonoma is a very rare tumor of the islet cells of the pancreas, which leads to an excess of the hormone glucagon in the blood.TumorA tumor is an abnormal growth of body tissue. Tumors can be cancerous (malignant) or noncancerous (benign).Read Article Now Book Mark Article Causes Glucagonoma is usually cancerous (malignant). The cancer tends to spread and get worse if not treated.This cancer affects some of the islet cells of the pancreas. As a result, the affected islet cells produce too much of the hormone glucagon.The cause is unknown. Genetic factors play a role in some cases. A family history of the syndrome multiple endocrine neoplasia type I (MEN I) is a risk factor.MEN IMultiple endocrine neoplasia (MEN) type I is a disease in which one or more of the endocrine glands are overactive or forms a tumor. It is passed do...ImageRead Article Now Book Mark Article Symptoms Symptoms of glucagonoma may include any of the following:Glucose intolerance (body has problem breaking down sugars) High blood sugar (hyperglycemia) Diarrhea Excessive thirst (due to high blood sugar) Frequent urination (due to high blood sugar) Increased appetite Inflamed mouth and tongue Nighttime (nocturnal) urination Skin rash on face, abdomen, buttocks, or feet that comes and goes, and moves around Weight loss In most cases, the cancer has already spread to the liver when it is diagnosed. Exams and Tests The health care provider will perform a physical exam and ask about your medical history and symptoms.Tests that may be done include:CT scan of the abdomen CT scan of the abdomenAn abdominal CT scan is an imaging method. This test uses x-rays to create cross-sectional pictures of the belly area. CT stands for computed tomog...ImageRead Article Now Book Mark Article Glucagon level in the blood Glucagon level in the bloodA glucagon blood test measures the amount of a hormone called glucagon in your blood. Glucagon is produced by specific cells in the pancreas. It he...Read Article Now Book Mark Article Glucose level in the blood Glucose level in the blood A blood sugar test measures the amount of a sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the...ImageRead Article Now Book Mark Article Treatment Surgery to remove the tumor before it spreads is usually recommended. Chemotherapy may be done when surgery is not possible.ChemotherapyThe term chemotherapy is used to describe cancer-killing drugs. Chemotherapy may be used to:Cure the cancerShrink the cancerPrevent the cancer from ...ImageRead Article Now Book Mark Article Support Groups You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.Cancer support groupThe following organizations are good resources for information on cancer:American Cancer Society. Support and online communities. www. cancer. org/...Read Article Now Book Mark Article Outlook (Prognosis) Approximately 60% of these tumors are cancerous. It is common for this cancer to spread to the liver. Only about 20% of people can be cured with surgery.If the tumor is only in the pancreas and surgery to remove it is successful, people have a 5-year survival rate of 85%. Possible Complications The cancer can spread to the liver. High blood sugar level can cause problems with metabolism and tissue damage.MetabolismMetabolism refers to all the physical and chemical processes in the body that convert or use energy, such as:BreathingCirculating bloodControlling bo...ImageRead Article Now Book Mark Article When to Contact a Medical Professional Contact your provider if you notice symptoms of glucagonoma.Open ReferencesReferencesAsban A, Patel AJ, Reddy S, Wang T, Balentine CJ, Chen H. Cancer of the endocrine system. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 68.National Cancer Institute website. Pancreatic neuroendocrine tumors (islet cell tumors) treatment (PDQ) - health professional version. www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq. Updated August 19, 2022. Accessed December 15, 2022.Newey PJ, Thakker RV. Multiple endocrine neoplasia. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 42.AllVideoImagesTogPancreas - illustration The pancreas is an elongated, tapered gland that is located behind the stomach and secretes digestive enzymes and the hormones insulin and glucagon.PancreasillustrationPancreas - illustration The pancreas is an elongated, tapered gland that is located behind the stomach and secretes digestive enzymes and the hormones insulin and glucagon.PancreasillustrationRelated Information Tumor(Condition)Metastasis(Special Topic)Cancer(Condition)Multiple endocrine neoplasia (MEN) I(Condition) Review Date: 10/16/2022 Reviewed By: Mark Levin, MD, Hematologist and Oncologist, Monsey, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited. © 1997- All rights reserved. A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.Content is best viewed in IE9 or above, Firefox and Google Chrome browser.
GlucagonomaMEN I - glucagonomaGlucagonoma is a very rare tumor of the islet cells of the pancreas, which leads to an excess of the hormone glucagon in the blood.TumorA tumor is an abnormal growth of body tissue. Tumors can be cancerous (malignant) or noncancerous (benign).Read Article Now Book Mark Article Causes Glucagonoma is usually cancerous (malignant). The cancer tends to spread and get worse if not treated.This cancer affects some of the islet cells of the pancreas. As a result, the affected islet cells produce too much of the hormone glucagon.The cause is unknown. Genetic factors play a role in some cases. A family history of the syndrome multiple endocrine neoplasia type I (MEN I) is a risk factor.MEN IMultiple endocrine neoplasia (MEN) type I is a disease in which one or more of the endocrine glands are overactive or forms a tumor. It is passed do...ImageRead Article Now Book Mark Article Symptoms Symptoms of glucagonoma may include any of the following:Glucose intolerance (body has problem breaking down sugars) High blood sugar (hyperglycemia) Diarrhea Excessive thirst (due to high blood sugar) Frequent urination (due to high blood sugar) Increased appetite Inflamed mouth and tongue Nighttime (nocturnal) urination Skin rash on face, abdomen, buttocks, or feet that comes and goes, and moves around Weight loss In most cases, the cancer has already spread to the liver when it is diagnosed. Exams and Tests The health care provider will perform a physical exam and ask about your medical history and symptoms.Tests that may be done include:CT scan of the abdomen CT scan of the abdomenAn abdominal CT scan is an imaging method. This test uses x-rays to create cross-sectional pictures of the belly area. CT stands for computed tomog...ImageRead Article Now Book Mark Article Glucagon level in the blood Glucagon level in the bloodA glucagon blood test measures the amount of a hormone called glucagon in your blood. Glucagon is produced by specific cells in the pancreas. It he...Read Article Now Book Mark Article Glucose level in the blood Glucose level in the blood A blood sugar test measures the amount of a sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the...ImageRead Article Now Book Mark Article Treatment Surgery to remove the tumor before it spreads is usually recommended. Chemotherapy may be done when surgery is not possible.ChemotherapyThe term chemotherapy is used to describe cancer-killing drugs. Chemotherapy may be used to:Cure the cancerShrink the cancerPrevent the cancer from ...ImageRead Article Now Book Mark Article Support Groups You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.Cancer support groupThe following organizations are good resources for information on cancer:American Cancer Society. Support and online communities. www. cancer. org/...Read Article Now Book Mark Article Outlook (Prognosis) Approximately 60% of these tumors are cancerous. It is common for this cancer to spread to the liver. Only about 20% of people can be cured with surgery.If the tumor is only in the pancreas and surgery to remove it is successful, people have a 5-year survival rate of 85%. Possible Complications The cancer can spread to the liver. High blood sugar level can cause problems with metabolism and tissue damage.MetabolismMetabolism refers to all the physical and chemical processes in the body that convert or use energy, such as:BreathingCirculating bloodControlling bo...ImageRead Article Now Book Mark Article When to Contact a Medical Professional Contact your provider if you notice symptoms of glucagonoma.Open ReferencesReferencesAsban A, Patel AJ, Reddy S, Wang T, Balentine CJ, Chen H. Cancer of the endocrine system. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 68.National Cancer Institute website. Pancreatic neuroendocrine tumors (islet cell tumors) treatment (PDQ) - health professional version. www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq. Updated August 19, 2022. Accessed December 15, 2022.Newey PJ, Thakker RV. Multiple endocrine neoplasia. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 42.